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The Global Gene Synthesis Market Size was $1,110,000 thousand in 2021 and is predicted to grow with a CAGR of 18.4%, by generating a revenue of $5,984,016.7 thousand by 2031.
The COVID-19 pandemic positively impacted the gene synthesis market share growth. In the initial days of pandemic, the gene synthesis market observed a negative growth owing to strict regulations and lockdowns imposed by the government owing to which the many research centers, institutions and biotechnological companies were closed for a few months. This severely decreased the demand for laboratory supplies like gene synthesizers, equipment, and reagents and kits. But, as soon as the infection cases increased across the globe, the demand for highly effective vaccine and drugs grew which, in turn, positively impacted the global gene synthesis market revenue growth in the pandemic era. Gene synthesis technique helps the scientists to understand the gene expression of any organism’s DNA and can also help in altering the gene expression. Thus, the scientists used gene synthesis to study the expression of corona virus and develop the appropriate vaccine to control the viral gene expression. Such factors have positively impacted the market growth in the pandemic period.
Rising prevalence of genetic diseases like cancer, and cognitive impairment among people, globally, due to many factors like genetic inheritance, or any external environment trigger like exposure to harmful radiation or chemicals have increased the demand for new and effective vaccines which has boosted the application of gene synthesis among researchers and scientists. Gene synthesis offers many advantages such as it facilitates the production of DNA tools by producing recombinant, mutant, or entirely unique DNA sequences without a template that would be difficult to manufacture using conventional molecular cloning procedures. To support various research applications, a large range of different sorts of sequences can be created using gene synthesis techniques. Additionally, DNA sequences, RNA and oligos with altered nucleotides or DNA-RNA hybrid backbones can also be created with the help of gene synthesis technology. Such factors are likely to generate huge gene synthesis market opportunity in the forecast time period.
Gene synthesis market share growth is expected to be constrained by the challenges associated with adopting the gene synthesis techniques and the high cost of the procedure in some regions. The market expansion may also be hampered by the industry's intense competition and protracted procurement timeframes. Gene synthesis techniques for DNA editing and synthesis make it simpler to alter biological agents and systems. With the aid of these technologies, illness or toxic DNA can be produced and unintentionally or purposefully administered to the patients. All of these variables are projected to restrain the growth of the gene synthesis market's revenue in the future.
Scientific advancements, introduction, and combination of new technologies for research and development are expected to boost gene synthesis market share growth in the forecast time period. Gene synthesis and molecular cloning can be used together to create synthetic products that are ready for use in research applications. Placing artificial genes into plasmid vectors has several benefits, including protecting the DNA from deterioration during storage, enabling complete sequence verification using primer sites on the vector that flank the gene insert, facilitating clonal amplification in a bacterial host that is transformation-competent, and making it easier to shuttle the artificial gene into expression vectors for transfection or electroporation into target host cells for temporary or stable effects.
Apart from this, many companies in the market are also using various growth strategies to enhance their business and increase their market share. For instance, according to an official news by Allozymes, on December 07, 2022, global leader in providing life science research tools and services, GenScript Biotech Corporation, announced its collaboration with Singapore-based startup biotech company Allozymes to significantly speed up the enzyme discovery and development process. For applications in a variety of industries, including pharmaceuticals, cosmetics, and food & beverage, GenScript will supply the mutant libraries' generation and expression, and Allozymes will provide ultra-high-throughput screening services. Such factors are further anticipated to increase gene synthesis market share growth in the projected time span.
The gene synthesis market is segmented on the basis of method, end user, and region.
Method:
By method, the market has been divided into solid phase synthesis, PCR based enzyme synthesis, and CHIP based DNA synthesis. Among these, the solid phase synthesis segment had a dominant market share in 2021 and PCR based enzyme is anticipated to have the fastest growth in the forecast time period. A DNA sequence can be amplified millions or billions of times using PCR, creating plenty DNA copies that can be examined using other methods. Numerous research labs employ PCR, which also has significant uses in forensics, genetic testing, and diagnostics. For example, PCR is used to amplify genes linked to hereditary illnesses from patients' DNA. If a pathogen is present, it may be feasible to amplify portions of its DNA from a blood or tissue sample using PCR. This method can also be used to screen for bacteria or DNA viruses in a patient's body.
End User:
By end user, the market has been divided into academic and research institutes, biotech and pharmaceutical companies, diagnostic laboratories, and others. Among these, the academic & research institutes segment had a dominant market share in 2021 and is anticipated to have the fastest growth in the forecast time period. This is attributed to people's growing preference for research environments for clinical research projects that conduct DNA synthesis procedures. The number of new companies entering the market is also being driven up by the increasing number of advancements and discoveries in biotechnology and pharmaceuticals. To expedite their research programs that need for the characterization and synthesis of gene fragments, research institutes are forming partnerships with service providers. Such factors are likely to drive gene synthesis market growth in the future.
Region:
The gene synthesis market in the Asia-Pacific region is anticipated to show the fastest growth by 2031 due to the area's rapidly expanding research and development activities and also rapidly developing healthcare and research laboratories infrastructure in the region. The presence of growing nations like China and India is propelling market expansion in the region. The government in these countries have increased the funding for research studies to provide efficient treatments and the interest in synthetic biology research. In addition, the prevalence of diseases is rising as a result of lifestyle modifications. Additionally anticipated market drivers are expanding R&D efforts, larger biotechnology companies entering the market, and improved healthcare infrastructure.
The key players profiled in this report include
For instance, on February 4, 2021, The Medicines Manufacturing Innovation Centre announced its collaboration with Novartis, AstraZeneca, Exactmer, and UK Research & Innovation. The major aim of the collaboration was to develop a sustainable and more cost-effective medicines manufacturing process for oligonucleotides: short strands of synthetic DNA or RNA on a large scale.
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