Gene Synthesis Market by Method (Solid Phase Synthesis, PCR Based Enzyme Synthesis, and CHIP Based DNA Synthesis), End User (Academic and Research Institutes, Biotech and Pharmaceutical Companies, Diagnostic Laboratories and Other), and Regional Analysis (North America, Europe, Asia-Pacific, and LAMEA): Global Opportunity Analysis and Industry Forecast, 2022-2031

Global Gene Synthesis Market Analysis

The Global Gene Synthesis Market Size was $1,110,000 thousand in 2021 and is predicted to grow with a CAGR of 18.4%, by generating a revenue of $5,984,016.7 thousand by 2031.

Global Gene Synthesis Market Synopsis

The demand for personalized medicine and therapeutics for various chronic diseases, as well as increased government funding for genomics, are the main drivers of the growth of the gene synthesis market. The gene synthesis market share is expected to be driven further owing to rising research and development in the fields of genomics and next-generation sequencing. The gene synthesis has gained popularity in recent years because customized medicine strives to give each patient a treatment plan that is specifically designed for them based on the molecular basis of their illness. Huge amounts of health-related data and insights are being produced by healthcare technology, genomics, connected devices, big data analytics, and artificial intelligence, allowing healthcare providers to provide better and more rapid diagnostic and treatment services by making more knowledgeable treatment decisions.

The possibility of an unintentional or intentional biological event has increased as a consequence of new techniques for DNA editing and synthesis that make it simpler to alter biological agents and systems. With the aid of gene synthesis, the researchers can easily manipulate any gene or DNA, thereby making a whole new genome. These technologies can enable the generation of pathogen or toxin DNA that may be intentionally or unintentionally misapplied. This factor is expected to hinder the market expansion of gene synthesis market in the forecast time period.

Increased government support through increased funding for gene development and expanded reimbursement policies to enable common people to benefit from newly developed therapies aids in accelerating the market for gene synthesis in response to rising demand.

Region-wise, the North America gene synthesis market accounted for a dominating market share in 2021. The regional growth is majorly attributed to extensive research going on in the field of DNA and gene synthesis, synthetic biology and more by the researchers.  

Gene Synthesis Overview

Gene synthesis is the chemical synthesis of a DNA strand. Unlike cell- or PCR-based DNA replication, gene synthesis does not require a template strand. Instead, as nucleotides are added to a single-stranded molecule over the course of gene synthesis, it acts as a template for the creation of a complimentary strand. Gene synthesis is the pillar technology on which the field of synthetic biology is based. Nucleic acids perform a wide range of biological tasks, from mediating cell-cell communication and encoding proteins to controlling gene expression in the nucleus and constructing biofilms from extracellular DNA. To examine these roles, synthetic genes are used by researchers and scientists.

COVID-19 Impact on Global Gene Synthesis Market

The COVID-19 pandemic has had both positive and negative impact on the gene synthesis industry. In the initial time of pandemic, the cell and gene therapy (CGT) sector experienced severe disruption as a result of the coronavirus 2019 (COVID-19), which has presented significant challenges in the supply of materials, production, and logistics operations. The majority of enterprises and research projects worldwide ended at the beginning of the COVID-19 pandemic as a result of the rising SARS-CoV-2 infection rate, which also decreased demand for gene synthesizers in the market and their usage in laboratories.

As the pandemic progressed and the demand for vaccines increased significantly, globally, the use of gene synthesis techniques had been adopted by researchers and scientists to study the physiology of viral genome on human DNA. Such factors have driven the gene synthesis market share growth in the pandemic era.

Growing Prevalence of Diseases Globally Projected to Drive Market Growth

Due to the increasing frequency of infectious diseases worldwide, the need for effective drugs and vaccine has increased and this has triggered the researchers and scientists to pace up their research activities and develop effective treatment options for diseases like cancer and tumors. Chemical medications and biological treatments, such as gene therapy, are effective treatments for certain disorders. The treatment of endemic and infectious diseases has improved thanks to the use of genomics. It also enables to comprehend new drug resistance and find potential targets for vaccinations and novel therapies. Since it can be treated with recombinant DNA technology, DNA & RNA ribozyme, and single chain antibodies, gene therapy has drawn the attention of many researchers for the treatment of infectious disorders. All such factors are likely to drive global gene synthesis market share growth in the forecast time period.

To know more about global gene synthesis market drivers, get in touch with our analysts here.

High Cost of Gene Synthesis to Restrain Market Growth

The difficulties in using gene synthesis techniques and the high cost of the process in some places may limit their development, which would restrain the gene synthesis market share growth. Also, high levels of competitiveness in the medical technology sector and lengthy lead times for ways to obtain desired genes can also pose difficulties for the market's expansion. Gene synthesis provides new methods for DNA editing and synthesis that make it easier to change biological agents and systems. These technologies make it possible to create disease or toxin DNA that might be accidentally or purposefully misapplied. All such factors are likely to hinder gene synthesis market revenue growth in the forecast time period.

Scientific Advancements in the Research and Development Field in Pharmaceutical and Biotechnology Field to Drive the Market Growth

Increased next-generation sequencing research and development, government support for genomics, and rising demand for customized/personalized medicine and therapies for various chronic diseases are all factors contributing to the growth of the gene synthesis market. Personalized medicine has gained popularity in recent years because it tries to give each patient a treatment plan that is specifically designed for them based on the molecular cause of their illness.

Biological research has been transformed by gene synthesis technology. The ability to build or reprogram entire genomes and cells has freed scientists from the limitations of the traditional methods of altering one gene at a time. To expedite vaccine development, scientists can easily manufacture newly discovered viral genomes. Additionally, they can create sustainable biofuels and new cancer-fighting enzymes, increase crop yields, and lessen crops' susceptibility to common pests and plant diseases that threaten the availability of food and make the world hungrier. Apart from this, growing prevalence of new diseases across the world has boosted the researchers and scientists to pace up their research activities and understand the biology behind the infections like Zika virus and Monkey pox using gene synthesis methods and thereby developing a strong vaccine portfolio against them. All these factors are likely to propel the gene synthesis market growth in the forecast time period.

To know more about global gene synthesis market opportunities, get in touch with our analysts here.

Global Gene Synthesis Market, By Method

By method, the market has been divided into solid phase synthesis, PCR based enzyme synthesis, and CHIP based DNA synthesis. Among these, the solid phase synthesis segment had a dominant market share in 2021 and PCR based enzyme is anticipated to have the fastest growth in the forecast time period.

Global Gene Synthesis Market Size, by Method, 2021

Source: Research Dive Analysis

The solid phase synthesis segment accounted for a dominant market share in 2021. The term "solid phase" refers to a conventional method of producing artificial genes that has a greater accuracy rate. In the solid-phase gene synthesis process, the molecules are separately synthesized and bound in an ionic bond to a solid surface known as controlled porosity glass beads. Such factors are responsible for the growth of gene synthesis market share in the forecast time frame.

Global Gene Synthesis Market, By End User

By end user, the market has been divided into academic and research institutes, biotech and pharmaceutical companies, diagnostic laboratories and other. Among these, the academic & research institutes segment had a dominant market share in 2021 and is anticipated to have the fastest growth in the forecast time period.

Global Gene Synthesis Market Growth, by End User, 2021

Source: Research Dive Analysis

The academic and research institutes segment accounted for a dominant market share in 2021. Government and academic institutions are working to develop novel therapeutics using gene synthesis techniques. This has resulted in more government support for chronic disease development sector, better gene treatment, and new technologies, as well as more research and development and enhanced usage.

Global Gene Synthesis Market, Regional Insights

The gene synthesis market was analyzed across North America, Europe, Asia-Pacific, and LAMEA.

Global Gene Synthesis Market Size & Forecast, by Region, 2021-2031 ($Thousand)

Source: Research Dive Analysis

The Gene Synthesis Market in North America to be the Most Dominant

The North America gene synthesis market size accounted for a dominating market share in 2021. The region offers tremendous opportunity for the growth of the gene synthesis market.  The market for gene synthesis is expected to grow in North America owing to the region's growing chronic disease rates, higher gene therapy, and expanded research and development on new gene-based technologies. Also, established technologically advanced research and development centers and availability of experienced researchers in the region are further anticipated to drive the market growth.

Competitive Scenario in Global Gene Synthesis Market

Investment and agreement are common strategies followed by major market players.

Source: Research Dive Analysis

The key players profiled in this report include Genscript Biotech Corporation, Thermo Fisher Scientific, Inc., Brooks Automation, Inc., Boster Biological Technology, Twist Bioscience Corporation, Danaher Corporation, Biomatik Corporation, ProteoGenix, ProMab Biotechnologies, Inc., and OriGene Technologies, Inc.